![]() Increases in glycosylated hemoglobin (HbA1c) and fasting serum glucose levels have been reported with statin use.These reported symptoms are generally not serious and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks). There have been rare post-marketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with statin use.If an alternate etiology is not found, the statin should not be restarted. If serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs during treatment, therapy should be interrupted. Healthcare professionals should perform liver enzyme tests before initiating statin therapy in patients and as clinically indicated thereafter.Patients should report side effects from the use of statins to the FDA MedWatch program, using the information in the "Contact FDA" box at the bottom of the page.Patients should contact their healthcare professional if they have any questions or concerns about statins.Certain medicines should never be taken (are contraindicated) with lovastatin (Mevacor) (see Lovastatin Dose Limitations below).Increases in blood sugar levels have been reported with statin use.These reported events were generally not serious and went away once the drug was no longer being taken. Memory loss and confusion have been reported with statin use. ![]() Patients should notify their healthcare professional right away if they have the following symptoms: unusual fatigue or weakness loss of appetite upper belly pain dark-colored urine or yellowing of the skin or the whites of the eyes.
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